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[Tissue plasminogen activator and diabetes mellitus]
P Galajda1, E Martinka, P Kubisz
1I. interná klinika MFN, Martin.
Vnitrni Lekarstvi
|July 28, 1999
Abstract:
tPA has been the independent risk factor of the thrombosis associated with atherosclerosis. There are increased tPA levels in type 1 diabetic patients with vascular complications and tPA is endothelial injury marker in this case. In type 2 diabetes mellitus elevated tPA antigen levels in early disease stage are caused by increased production of complexes with inhibitor (PAI-1) and tPA or fibrinolytic activity has been decreased.