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Thromboxane A2-induced phosphatidylcholine hydrolysis in porcine vascular smooth muscle cells

N Nakahata1, H Takano, Y Ohizumi

  • 1Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan. nakahata@mail.pharm.tohoku.ac.jp

European Journal of Pharmacology
|July 28, 1999
PubMed

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The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...