Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Asthma: an inflammatory mediator soup.

U S Björnsdottir1, D M Cypcar

  • 1Pulmonary Department, University Hospital of Iceland, Vifilstadir.

Allergy
|July 28, 1999
PubMed
Summary

Asthma involves reversible airway obstruction and inflammation, driven by immune cells releasing mediators. Early anti-inflammatory treatment is crucial for managing this complex respiratory condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of changes to reimbursement of fixed combinations of inhaled corticosteroids and long-acting β₂ -agonists in obstructive lung diseases: a population-based, observational study.

International journal of clinical practice·2014
Same author

Potential negative consequences of non-consented switch of inhaled medications and devices in asthma patients.

International journal of clinical practice·2013
Same author

[Latex allergy - an emerging health care problem.].

Laeknabladid·2010
Same author

Contribution of ADAM33 polymorphisms to the population risk of asthma.

Thorax·2005
Same author

Obesity and nocturnal gastro-oesophageal reflux are related to onset of asthma and respiratory symptoms.

The European respiratory journal·2004
Same author

Sensitization to house dust mites in Reykjavik, Iceland, in the absence of domestic exposure to mites.

Allergy·2004

Area of Science:

  • Immunology
  • Pulmonology
  • Pathophysiology

Background:

  • Asthma is characterized by reversible airway obstruction, inflammation, and bronchial hyperresponsiveness.
  • Airway obstruction results from bronchospasm, inflammation, and mucus production.
  • Inflammation plays a central role in asthma pathogenesis, contributing to airflow limitation and hyperresponsiveness.

Purpose of the Study:

  • To elucidate the complex inflammatory pathways involved in asthma pathogenesis.
  • To highlight the role of immune cells and mediators in airway inflammation and damage.
  • To emphasize the importance of early recognition and anti-inflammatory treatment in asthma management.

Main Methods:

  • Review of inflammatory processes triggered by allergens in asthma.
  • Analysis of immune cell activation, mediator release, and cytokine production.
  • Examination of endothelial cell activation and leukocyte adhesion molecule expression.

Main Results:

  • Inhaled allergens activate mast cells and macrophages, releasing proinflammatory mediators.
  • T helper cells differentiate into Th2 phenotype, promoting IgE synthesis and eosinophil infiltration.
  • Cytokines like IL-1, TNF-alpha, and IFN-gamma activate endothelial cells, increasing adhesion molecule expression for leukocyte migration.

Conclusions:

  • Asthma pathogenesis involves a complex interplay of inflammatory cells and mediators.
  • Inflammatory cells and mediators contribute to airway damage and perpetuate the inflammatory process.
  • Early recognition and anti-inflammatory treatment are essential for managing asthma effectively.

Related Experiment Videos