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Hypertension and dementia.

M Fujishima1, T Tsuchihashi

  • 1Second Department of Internal Medicine, Kyushu University, Fukuoka, Japan.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|July 28, 1999
PubMed
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Vascular dementia prevalence declined in Japanese men, while Alzheimer's disease remained stable. Hypertension is a key risk for vascular dementia, but its role in Alzheimer's disease requires further study.

Area of Science:

  • Neurology
  • Epidemiology
  • Geriatrics

Background:

  • Vascular dementia (VD) is more common in Japan, unlike Alzheimer's disease (AD) prevalent in Western countries.
  • The Hisayama study observed a decrease in VD prevalence among men over a 7-year period (1985-1992).
  • AD incidence rises with age, particularly in those 85 and older.

Purpose of the Study:

  • To analyze trends in vascular dementia and Alzheimer's disease prevalence in a Japanese community.
  • To identify and compare risk factors for VD and AD.
  • To explore the controversial role of hypertension in AD pathogenesis and prevention.

Main Methods:

  • Community-based cohort study (Hisayama study) in Japan.
  • Longitudinal follow-up over 7 years (1985-1992).

Related Experiment Videos

  • Analysis of prevalence, incidence, and risk factors for dementia subtypes.

    • Main Results:

    • Prevalence of VD decreased in men; AD prevalence remained unchanged in men and women.
    • Hypertension is a significant risk factor for VD.
    • Risk factors for AD include age, family history, low education, and low physical activity; hypertension's role is debated.

    Conclusions:

    • Vascular factors are increasingly recognized in AD pathogenesis.
    • Antihypertensive treatment may offer preventive benefits for dementia, especially AD.
    • Further research is needed to clarify the effectiveness of antihypertensive treatment in preventing AD.