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Inhibition of cathepsin D by tripeptides containing statine analogs
M Bessodes1, K Antonakis, J Herscovici
1CNRS UMR 133, ENSCP, Paris, France. bessodes@infobiogen.fr
Biochemical Pharmacology
|July 28, 1999
Abstract:
Various analogs of statine, a remarkable amino acid component of the protease inhibitor pepstatine, were synthesized and evaluated as tripeptide derivatives for their activity against cathepsin D and HIV-1 protease.