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Increased plasma nitrite level in cardiac failure.

G Ramesh1, J S Varma, N K Ganguly

  • 1Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh-160012, India.

Journal of Molecular and Cellular Cardiology
|July 29, 1999
PubMed
Summary
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Patients with cardiac failure show elevated plasma nitrite levels, indicating increased nitric oxide production. This suggests nitric oxide plays a role in myocardial dysfunction and vascular changes associated with heart failure.

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • Nitric oxide (NO) is a key molecule in cardiovascular physiology.
  • Its role in the pathogenesis of cardiac failure is increasingly recognized.

Purpose of the Study:

  • To investigate plasma nitrite levels, a marker of NO metabolism, in patients with cardiac failure.
  • To correlate nitrite levels with cardiac function and disease severity in rheumatic heart disease.

Main Methods:

  • Plasma nitrite levels were measured in three groups: cardiac failure patients (Group I), non-failing heart disease patients (Group II), and healthy controls (Group III).
  • Cardiac function was assessed using echocardiographic parameters and New York Heart Association (NYHA) functional class.

Main Results:

  • Group I exhibited significantly higher plasma nitrite levels (242.2 n m) compared to Group II (142.6 n m) and Group III (102.7 n m).

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  • Elevated nitrite levels correlated with impaired myocardial contractile function (e.g., reduced ejection fraction) and worse NYHA functional class in rheumatic heart disease patients.

    • Conclusions:

    • Plasma nitrite is increased in patients with cardiac failure due to rheumatic valvular heart disease.
    • These findings suggest enhanced nitric oxide production contributes to myocardial dysfunction and altered vascular responses in cardiac failure.