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Dopaminergic influence on cardiovascular responses to exercise stress in hypertensive subjects
M Blanco1, N Hurtado, I Jelambi
1Clinical Pharmacology Unit, Vargas Medical School, Central University of Venezuela, Caracas.
American Journal of Therapeutics
|January 1, 1997
Abstract:
Ten hypertensive subjects were studied at the Vargas Medical School in Caracas, Venezuela. They were submitted to submaximal treadmill exercises according to Bruce's protocol under treatment with dopaminergic drugs (metoclopramide, bromocriptine). Before and during submaximal exercises, metoclopramide caused a hypotensive effect accompanied by an increased heart rate, which was blocked by the administration of bromocriptine. We conclude that a probable dopaminergic modulatory influence takes place during exercise.