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Primary ciliary dyskinesia in Newfoundland dogs
The Veterinary Record
|July 29, 1999
Summary
Primary ciliary dyskinesia, a genetic disorder affecting cilia, was diagnosed in Newfoundland dogs. This study details the clinical signs, ultrastructural defects, and autosomal recessive inheritance of this condition in the breed.
Area of Science:
- Veterinary Medicine
- Genetics
- Respiratory Medicine
Background:
- Primary ciliary dyskinesia (PCD) is a rare genetic disorder affecting motile cilia.
- It leads to impaired mucus clearance and recurrent respiratory infections.
Observation:
- Three Newfoundland dogs presented with chronic rhinitis and bronchopneumonia.
- Radiographs revealed severe bronchopneumonia and cardiac apex displacement.
- Semen analysis showed abnormal sperm morphology and motility.
Findings:
- Transmission electron microscopy confirmed ultrastructural ciliary defects, including absent dynein arms and disorganized basal bodies.
- Pedigree analysis indicated a monogenic autosomal recessive inheritance pattern.
- This is the first report of primary ciliary dyskinesia in Newfoundland dogs.
Implications:
- This finding expands the known breeds affected by primary ciliary dyskinesia.
- Understanding the genetic basis is crucial for diagnosis and breeding programs.
- Further research may elucidate specific genetic mutations in affected Newfoundlands.