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PATIC: a conformationally constrained photoisomerizable amino acid
J Zhang1, D A James, G A Woolley
1Department of Chemistry, University of Toronto, Canada.
Abstract:
The synthesis of a conformationally constrained photoisomerizable amino acid, phenylazo-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid (PATIC), is described. This amino acid can be incorporated into peptides using standard Fmoc procedures and can be accommodated within alpha-helical structures albeit with some loss of stability of the structure. PATIC can serve as a useful building block for the synthesis of photoregulated peptides and proteins.