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Related Experiment Videos

Fluorescence microlymphography of the upper extremities. Evaluation with a new computer programme.

S Läuchli1, L Haldimann, A J Leu

  • 1Department of Medicine, University Hospital, Zürich, Switzerland.

International Angiology : a Journal of the International Union of Angiology
|July 29, 1999
PubMed
Summary

This study used fluorescence microlymphography to measure initial lymphatic function in healthy arms, establishing normal values for comparison with lymphedema patients.

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Area of Science:

  • Vascular Medicine
  • Lymphatic System Imaging
  • Dermatology

Background:

  • Assessing superficial lymphatic function is crucial for diagnosing lymphedema.
  • Establishing normal reference values for lymphatic imaging is necessary for clinical comparison.

Purpose of the Study:

  • To evaluate the initial lymphatics of the superficial skin in healthy volunteers.
  • To establish control values for comparison with lymphedema patients using fluorescence microlymphography.

Main Methods:

  • Fluorescence microlymphography performed on the hand dorsum, lower, and upper arms of 12 healthy subjects.
  • Subepidermal injection of FITC-dextran followed by video recording with a fluorescence microscope and CCD camera.
  • Measurement of maximum contrast medium spread and lymph capillary network area 10 minutes post-injection.

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Main Results:

  • Mean lymph capillary network area: 95.3+/-41.3 mm2 (upper arm) and 89.4+/-45.5 mm2 (lower arm).
  • Mean maximum spread: 4.8+/-3.5 mm (upper arm) and 4.4+/-3.7 mm (lower arm).
  • Mean lymph capillary diameter: 84.1+/-19.9 microm (upper arm) and 75.5+/-14.8 microm (lower arm).

Conclusions:

  • Lymphatic capillary network extension in the arms is comparable to lower extremities.
  • Area measurement is a more appropriate assessment of lymphatic network size than maximum spread due to its 2D, irregular nature.