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Related Experiment Videos

Ascorbic acid and alpha-tocopherol attenuate methylmalonic acid-induced convulsions.

M R Fighera1, C M Queiroz, M P Stracke

  • 1Departmento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Brasil.

Neuroreport
|July 29, 1999
PubMed
Summary

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Alpha-tocopherol and ascorbic acid reduced methylmalonic acid (MMA)-induced seizures in rats. This suggests free radicals may play a role in MMA

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pharmacology

Background:

  • Methylmalonic acid (MMA) is linked to neurological dysfunction.
  • Oxidative stress is implicated in various neurological disorders.

Purpose of the Study:

  • To investigate the neuroprotective effects of alpha-tocopherol and ascorbic acid against MMA-induced convulsions.
  • To explore the potential role of free radicals in MMA's convulsant action.

Main Methods:

  • Adult male rats received chronic alpha-tocopherol or melatonin, or acute ascorbic acid.
  • Methylmalonic acid (MMA) was administered intrastriatally to induce convulsions.
  • Convulsive episodes and rotational behavior were monitored.

Main Results:

Related Experiment Videos

  • Alpha-tocopherol and ascorbic acid significantly reduced the duration of MMA-induced clonic and tonic-clonic convulsions.
  • These antioxidants also decreased MMA-induced rotational behavior.
  • Melatonin did not show significant protective effects.

Conclusions:

  • Free radical generation is likely involved in the neurotoxic effects of methylmalonic acid.
  • Alpha-tocopherol and ascorbic acid exhibit neuroprotective properties against MMA-induced seizures.
  • Further research into antioxidant therapies for MMA-related neurological issues is warranted.