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Related Experiment Videos

Olanzapine overdose with serum concentrations.

L G Cohen1, A Fatalo, B T Thompson

  • 1Pediatric Psychopharmacology Unit, Department of Psychiatry, Massachusetts, USA. lcohen1@partners.org

Annals of Emergency Medicine
|July 29, 1999
PubMed
Summary
This summary is machine-generated.

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Olanzapine overdose can cause severe central nervous system depression and symptoms mimicking neuroleptic malignant syndrome. Prompt medical care, including intubation and supportive treatment, led to a patient's full recovery after an 800 mg overdose.

Area of Science:

  • Pharmacology
  • Clinical Toxicology
  • Psychiatry

Background:

  • Olanzapine is an atypical antipsychotic used for schizophrenia and psychotic mood disorders, with millions of prescriptions worldwide.
  • Increased olanzapine use and patient suicide risk necessitate understanding overdose effects.
  • This case report details an 800 mg olanzapine overdose.

Observation:

  • The patient presented with profound central nervous system depression and tachycardia within 2 hours of ingestion.
  • Clinical signs included fever, mutism, agitation, dystonia, akathisia, elevated creatine kinase, and increased leukocyte count.
  • These symptoms were clinically similar to neuroleptic malignant syndrome.

Findings:

  • The overdose primarily caused significant central nervous system depression and tachycardia.

Related Experiment Videos

  • Observed symptoms largely mirrored those of neuroleptic malignant syndrome.
  • Serum concentrations were monitored throughout the clinical course.

    • Implications:

    • This case highlights the potential severity of olanzapine overdose.
    • It underscores the importance of recognizing symptoms resembling neuroleptic malignant syndrome in overdose cases.
    • Effective management involves supportive care, including airway management and decontamination.