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Related Experiment Videos

Olanzapine overdose mimicking opioid intoxication.

G F O'Malley1, S Seifert, K Heard

  • 1Rocky Mountain Poison and Drug Center, Denver, CO, USA. geraldo@pol.net

Annals of Emergency Medicine
|July 29, 1999
PubMed
Summary

Acute overdose of olanzapine (Zyprexa) can cause severe central nervous system depression and pupillary constriction. This finding is crucial for diagnosing patients with altered mental status and miosis.

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Area of Science:

  • Pharmacology
  • Toxicology
  • Emergency Medicine

Background:

  • Published literature suggests a generally benign course for olanzapine overdose.
  • Supratherapeutic ingestion of olanzapine can lead to a wide range of clinical effects.

Purpose of the Study:

  • To report the previously undocumented phenomenon of pupillary constriction in acute olanzapine overdose.
  • To highlight the potential for severe central nervous system depression in olanzapine overdose.

Main Methods:

  • Case series of 4 patients presenting with acute olanzapine overdose.
  • Clinical observation and supportive care management.

Main Results:

  • All 4 patients experienced significant central nervous system depression.

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  • Two patients required advanced airway support.
  • A previously unreported finding of pupillary constriction was observed in all patients.

    • Conclusions:

    • Olanzapine overdose can cause profound CNS depression and miosis.
    • Olanzapine should be considered in the differential diagnosis for patients with depressed mental status and miosis.
    • All patients recovered with supportive care, indicating the importance of prompt medical intervention.