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Severe lactic acidosis induced by nucleoside analogues in an HIV-infected man
P M Roy1, J P Gouello, I Pennison-Besnier
1Department of Emergency Medicine, University Hospital of Angers, France. pmroy@chu-angers.fr
Annals of Emergency Medicine
|July 29, 1999
Abstract:
Nucleoside analogues can induce myopathy or hepatitis by means of mitochondrial dysfunction. We report the case of a 31-year-old man infected with HIV who had a severe lactic acidosis without muscle or liver symptoms. He improved after hemodialysis and withdrawal of antiviral drugs. Muscle and liver evaluation allowed us to ascribe lactic acidosis to a mitochondriopathy induced by zidovudine and didanosine.