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Related Experiment Videos

Immunisation against lactic acidosis in cattle.

Q Shu1, H S Gill, D W Hennessy

  • 1Department of Animal Science, University of New England, Armidale, NSW, 2351, Australia.

Research in Veterinary Science
|July 30, 1999
PubMed
Summary

Immunisation against lactic acid-producing bacteria, Streptococcus bovis and Lactobacillus, reduced the risk of lactic acidosis in steers. Vaccinated animals showed improved feed intake and lower lactate levels, suggesting a viable control strategy.

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Area of Science:

  • Veterinary immunology
  • Ruminant nutrition
  • Microbial disease control

Background:

  • Lactic acidosis is a significant metabolic disorder in cattle, often triggered by high-grain diets.
  • Lactic acid-producing bacteria, specifically Streptococcus bovis and Lactobacillus, play a crucial role in its pathogenesis.
  • Current control methods for lactic acidosis are limited, necessitating novel approaches.

Purpose of the Study:

  • To evaluate the effectiveness of vaccination against Streptococcus bovis and Lactobacillus for controlling lactic acidosis in steers.
  • To assess the impact of immunisation on bacterial populations, rumen lactate levels, and overall animal health.

Main Methods:

  • Ten steers were divided into two groups: one immunised with a vaccine containing S. bovis and Lactobacillus, and a non-immunised control group.

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  • Immunisation involved intramuscular injections with adjuvants (Freund's complete and incomplete) and booster doses.
  • Key parameters measured included antibody titres (IgG), feed intake, rumen pH, lactate concentration, and bacterial counts.

    • Main Results:

    • Immunisation led to significant increases in anti-S. bovis and anti-Lactobacillus IgG levels in saliva and serum.
    • Vaccinated steers exhibited higher feed intake and significantly lower rumen lactate concentrations compared to controls.
    • The immunised group had reduced populations of S. bovis and Lactobacillus, and fewer animals required withdrawal due to severe acidosis.

    Conclusions:

    • Vaccination against Streptococcus bovis and Lactobacillus is an effective strategy for reducing the incidence and severity of lactic acidosis in steers.
    • This immunisation approach offers a promising method for improving ruminant health and mitigating metabolic disorders associated with high-grain feeding.