Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunisation against lactic acidosis in cattle.

Q Shu1, H S Gill, D W Hennessy

  • 1Department of Animal Science, University of New England, Armidale, NSW, 2351, Australia.

Research in Veterinary Science
|July 30, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Cambridge Questionnaire for Apathy and Impulsivity Traits (CamQUAIT): a novel assessment tool for frontotemporal lobar degeneration-related syndromes.

PloS one·2026
Same author

[Association between residential green space exposure in maternal early pregnancy and the risk of congenital heart defects in offsprings in Zhejiang province].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2026
Same author

[Long-term management of right ventricular outflow tract dysfunction in repaired tetralogy of Fallot: an interpretation of the 2024 scientific statement from the American Heart Association].

Zhonghua xin xue guan bing za zhi·2026
Same author

A survey study of vaccine hesitancy among children to COVID-19 vaccination and the roles of parental and social media influence.

The Medical journal of Malaysia·2025
Same author

High tibial osteotomy and additive manufacture can significantly reduce the climate impact of surgically treating knee osteoarthritis.

The international journal of life cycle assessment·2025
Same author

Continuous Electrochemical Carbon Capture via Redox-Mediated pH Swing─Experimental Performance and Process Modeling.

The journal of physical chemistry letters·2025

Immunisation against lactic acid-producing bacteria, Streptococcus bovis and Lactobacillus, reduced the risk of lactic acidosis in steers. Vaccinated animals showed improved feed intake and lower lactate levels, suggesting a viable control strategy.

Area of Science:

  • Veterinary immunology
  • Ruminant nutrition
  • Microbial disease control

Background:

  • Lactic acidosis is a significant metabolic disorder in cattle, often triggered by high-grain diets.
  • Lactic acid-producing bacteria, specifically Streptococcus bovis and Lactobacillus, play a crucial role in its pathogenesis.
  • Current control methods for lactic acidosis are limited, necessitating novel approaches.

Purpose of the Study:

  • To evaluate the effectiveness of vaccination against Streptococcus bovis and Lactobacillus for controlling lactic acidosis in steers.
  • To assess the impact of immunisation on bacterial populations, rumen lactate levels, and overall animal health.

Main Methods:

  • Ten steers were divided into two groups: one immunised with a vaccine containing S. bovis and Lactobacillus, and a non-immunised control group.

Related Experiment Videos

  • Immunisation involved intramuscular injections with adjuvants (Freund's complete and incomplete) and booster doses.
  • Key parameters measured included antibody titres (IgG), feed intake, rumen pH, lactate concentration, and bacterial counts.

    • Main Results:

    • Immunisation led to significant increases in anti-S. bovis and anti-Lactobacillus IgG levels in saliva and serum.
    • Vaccinated steers exhibited higher feed intake and significantly lower rumen lactate concentrations compared to controls.
    • The immunised group had reduced populations of S. bovis and Lactobacillus, and fewer animals required withdrawal due to severe acidosis.

    Conclusions:

    • Vaccination against Streptococcus bovis and Lactobacillus is an effective strategy for reducing the incidence and severity of lactic acidosis in steers.
    • This immunisation approach offers a promising method for improving ruminant health and mitigating metabolic disorders associated with high-grain feeding.