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Deoxycholate-hydrogels: novel drug carrier systems for topical use
C Valenta1, E Nowack, A Bernkop-Schnürch
1Institute of Pharmaceutical Technology, University of Vienna, Althanstrasse 14, A-1090, Vienna, Austria. claudia.valenta@univie.ac.at
International Journal of Pharmaceutics
|July 30, 1999
Summary
Sodium deoxycholate (Na-DOC) forms thixotropic gels for novel topical drug delivery. These Na-DOC gels enhance drug permeation and offer advantages for pharmaceutical and cosmetic applications.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Sodium deoxycholate (Na-DOC) forms viscous, thixotropic gels with buffer systems.
- These gels are explored as novel drug delivery systems for topical applications.
Purpose of the Study:
- To evaluate Na-DOC gels as drug carriers for topical use.
- To investigate the impact of excipients like mannitol, glycerol, and xylitol on gel properties.
- To assess drug release and skin permeation characteristics.
Main Methods:
- Oscillatory measurements were used to determine the viscous modulus (G'/Pa) influenced by excipients.
- An optimized formulation (0.5% Na-DOC in PBS with 5% mannitol) was selected based on viscosity, distribution, and appearance.
- Drug release (rutin) through artificial membranes and permeation through rat skin were compared to HEC and NaC934 gels.
Main Results:
- Na-DOC gels demonstrated higher release rates of rutin compared to HEC and NaC934 gels.
- Permeation of rutin through excised rat skin was significantly higher with Na-DOC systems, indicating enhanced membrane permeability.
- Microbial stability was comparable to existing gel systems, necessitating preservation.
Conclusions:
- Na-DOC gels are effective, low molecular weight, multifunctional drug carriers.
- These gels act as penetration enhancers, improving drug delivery.
- The thixotropic nature of Na-DOC gels facilitates application to large skin areas and mucosal membranes, making them promising for pharmaceutical and cosmetic use.