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Related Experiment Video

Updated: Jun 21, 2026

Defining Substrate Specificities for Lipase and Phospholipase Candidates

Defining Substrate Specificities for Lipase and Phospholipase Candidates

Published on: November 23, 2016

Localization and possible functions of phospholipase D isozymes.

M Liscovitch¹, M Czarny, G Fiucci

¹Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.

Biochimica Et Biophysica Acta

|July 30, 1999

Summary

This summary is machine-generated.

Phospholipase D (PLD) activation regulates cell function and fate. Diverse PLD activities are found in cellular organelles, supporting signaling, vesicle transport, and cytoskeletal dynamics.

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Area of Science:

Cell Biology
Molecular Biology
Biochemistry

Background:

Extracellular signal molecules regulate cell function and fate through Phospholipase D (PLD) activation.
Mammalian cells exhibit multiple characterized PLD activities.
Several PLD genes have been cloned, advancing research in this area.

Purpose of the Study:

To explore the diverse roles and localization of PLD activities within cellular organelles.
To understand the involvement of PLD in fundamental cellular processes.

Main Methods:

Characterization of multiple PLD activities in mammalian cells.
Cloning of several PLD genes.
Localization studies of PLD activities in cellular organelles.

Main Results:

Evidence suggests diverse PLD activities are present in most, if not all, cellular organelles.
These activities are implicated in signal transduction pathways.
PLD activities also play roles in membrane vesicle trafficking and cytoskeletal dynamics.

Conclusions:

PLD is a key regulator of cellular processes, including signal transduction, membrane dynamics, and cytoskeleton organization.
The localization of PLD activities across various organelles highlights its widespread importance in cell biology.
Further research into specific PLD functions within organelles is warranted.