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Published on: March 24, 2015
[Thyroid disorders associated with interferon treatment in patients with chronic viral hepatitis or multiple
J I Diago1, D del Olmo, V Alcázar
1Secciones de Endocrinología, Hospital Severo Ochoa, Leganés, Madrid. cvazquez@hso.es
Background:
Alpha and beta interferon (IFN-alpha and beta) treatment is associated with the synthesis of thyroid autoantibodies and the development of autoimmune thyroid diseases.
Methods And Results:
We have retrospectively evaluated their effect in patients with chronic viral hepatitis (CH) (n = 118) and multiple esclerosis (ME) (n = 10). Thyroid dysfunction has been detected in 7.4% of patients, and seroconversion in 4.7%.
Conclusions:
Pre-treatment antithyroid antibodies do not predispose to altered thyroid function, after IFN therapy; their presence should not contraindicate IFN treatment.
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