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Trazodone in burning mouth pain: a placebo-controlled, double-blind study
T Tammiala-Salonen1, H Forssell
1Institute of Dentistry, Turku University, Finland.
Aims:
An 8-week parallel, placebo-controlled, double-blind trial evaluated the efficacy of the antidepressant trazodone in the treatment of chronic burning mouth pain.
Methods:
Thirty-seven carefully selected women aged 39 to 71 (mean 58.6 years) were randomized to receive either 200 mg of trazodone or a placebo in a similar manner. Pain and pain-related symptoms were evaluated on a visual analogue scale and other measures at 0, 2, 4, and 8 weeks.
Results:
There were no significant differences between the groups in treatment effects for pain or pain-related symptoms. Seven patients in the trazodone group and 2 in the placebo group failed to complete the trial because of side effects. The most common side effects were dizziness and drowsiness.
Conclusion:
In this controlled trial, trazodone failed to relieve burning mouth pain.
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