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Effects of an ionic and nonionic contrast agent on von Willebrand factor assessed during coronary angiography

G J Dehmer1, T C Nichols, S Li

  • 1Center for Thrombosis and Hemostasis, Department of Medicine (Cardiology Division), University of North Carolina, Chapel Hill, USA. dehmer.car1@mail.unch.unc.edu

This study shows an increase in von Willebrand factor antigen in blood collected from the coronary sinus shortly after coronary angiography with an ionic contrast agent (diatrizoate), but not a nonionic contrast agent (iohexol). These findings suggest that ionic contrast agents may cause more endothelial injury than nonionic contrast agents.

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