Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Suppressive therapy with levothyroxine for euthyroid diffuse and nodular goiter.

S Güllü1, M A Gürses, N Başkal

  • 1Department of Endocrinology and Metabolic Diseases, Ankara University Medical School, Turkey.

Endocrine Journal
|July 30, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Are sonographic characteristics of Hashimoto's thyroiditis related with immunologic parameters? A cross-sectional study.

Journal of endocrinological investigation·2024
Same author

[Assessment of the risk of occurrence of musculoskeletal disorders in a production unit].

Annales pharmaceutiques francaises·2022
Same author

Flexural behavior of 3D <i>para</i>-aramid/phenolic/nano (MWCNT) composites.

RSC advances·2022
Same author

Recombinant human thyrotropin <i>versus</i> thyroid hormone withdrawal in differentiated thyroid carcinoma follow-up: a single center experience.

Acta endocrinologica (Bucharest, Romania : 2005)·2022
Same author

Turkish pediatric residents' knowledge, perceptions, and practices of blood culture sampling.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2021
Same author

Comparative evaluation of re-use or replacement of dislocated 3-piece intraocular lenses with a scleral fixation technique.

Journal francais d'ophtalmologie·2019

Levothyroxine (L-T4) treatment effectively reduces goiter and thyroid nodule volumes in patients. Thyroglobulin levels do not reliably indicate treatment efficacy for these thyroid conditions.

Area of Science:

  • Endocrinology
  • Thyroidology
  • Pharmacology

Background:

  • Euthyroid goiters, both diffuse and nodular, are common thyroid conditions.
  • Levothyroxine (L-T4) therapy is a standard treatment for certain thyroid disorders.
  • The efficacy of L-T4 in reducing goiter and nodule volumes requires further evaluation.

Purpose of the Study:

  • To assess the effectiveness of Levothyroxine (L-T4) treatment on thyroid and nodule volumes.
  • To investigate the correlation between volume changes and serum thyroglobulin levels.
  • To evaluate L-T4's impact on thyroid hormone levels and TSH.

Main Methods:

  • A study involving 70 patients (35 diffuse goiter, 35 nodular goiter) treated with L-T4 for six months.
  • Measurements included serum thyroid hormones, TSH, thyroglobulin, and thyroid/nodule volumes at baseline and after treatment.

Related Experiment Videos

  • Radioactive iodine uptake was assessed pre-treatment.

    • Main Results:

    • Significant mean thyroid volume reduction of approximately 20% in diffuse goiter patients.
    • Thyroid nodules showed variable response: 31% had ≥50% volume reduction, 54% had 10-49% reduction.
    • L-T4 increased free T4/T3 and decreased TSH; higher baseline TSH correlated with greater volume reduction in diffuse goiter.

    Conclusions:

    • Suppressive thyroxine therapy is effective in reducing goiter and thyroid nodule size.
    • Thyroglobulin levels are not a reliable indicator for assessing L-T4 treatment efficacy in goiter patients.
    • L-T4 treatment favorably impacts thyroid hormone profiles and TSH levels.