Reperfusion therapy in cardiogenic shock complicating acute myocardial infarction

The most frequent cause of cardiogenic shock complicating acute myocardial infarction is extensive myocardial damage involving a relevant amount of myocardium. Treatment is aimed at support for the circulation with the use of drugs and mechanical devices and at restoration of perfusion to the ischemic myocardium as soon as possible. Therefore, emergency coronary angiography is indicated in all patients. Coronary angioplasty is the first option in patients with suitable anatomy because it is the fastest available technique able to recanalize the infarct-related vessel. Stenting of the infarct artery must be considered because stent implantation has been shown to improve results in comparison with the balloon alone. Complete revascularization is likely to offer a better outcome in patients with multivessel disease. Coronary surgery is indicated as first-line intervention in patients who have a coronary anatomy not suitable for angioplasty; it may also serve to complete revascularization in patients with multivessel disease initially treated with emergency coronary angioplasty. In a hospital without facilities for emergency coronary interventions, mechanical circulatory support with an intra-aortic balloon pump should be instituted and thrombolysis started; then patients should be transferred immediately to a tertiary center to undergo coronary angiography and revascularization procedures, if needed. In patients not benefiting from this aggressive revascularization strategy who develop irreversible extensive myocardial damage, heart transplantation must be considered.