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Updated: Jul 19, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Generalized lupus erythematosus profundus in a patient with genetic partial deficiency of C4
H C Nousari1, A Kimyai-Asadi, T T Provost
1Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. hnousari@welchlink.welch.jhu.edu
Abstract:
Lupus erythematosus profundus (LEP) is an unusual variant of cutaneous lupus erythematosus (CLE)that is characterized by chronic, recurrent inflammation of the subcutaneous tissue leading to fibrosis. It is found in the settings of both discoid and systemic lupus erythematosus. Generalized forms are extremely rare. We present a case of generalized LEP associated with genetic partial C4-deficiency.
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