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Related Experiment Video

Updated: Jul 6, 2026

Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation

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Published on: December 31, 2007

An activating immunoreceptor complex formed by NKG2D and DAP10.

J Wu¹, Y Song, A B Bakker

¹DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA.

Science (New York, N.Y.)

|July 31, 1999

Summary

Natural killer (NK) and T cells utilize the NKG2D-DAP10 receptor complex to target tumors. This complex activates immune responses against MICA-expressing cancer cells.

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Area of Science:

Immunology
Cell Biology
Molecular Biology

Background:

Immune receptors often consist of distinct ligand-binding and signal-transducing components.
DAP10 acts as a cell surface adaptor protein, forming an activating receptor complex with NKG2D.
NKG2D binds to MICA, a stress-inducible molecule associated with tumors.

Discussion:

The DAP10 cytoplasmic domain contains an SH2 domain-binding site.
This site recruits the p85 subunit of phosphatidylinositol 3-kinase (PI 3-kinase).
This recruitment facilitates NKG2D-dependent signal transduction.

Key Insights:

The NKG2D-DAP10 complex couples receptor binding to intracellular signaling pathways.
Recruitment of PI 3-kinase via DAP10 is crucial for signal transduction.
This mechanism enables natural killer (NK) and T cell activation.

Outlook:

Investigating the precise signaling events downstream of PI 3-kinase activation.
Exploring therapeutic strategies targeting the NKG2D-DAP10-MICA axis for cancer immunotherapy.
Understanding the role of this complex in other immune cell types or disease contexts.