Related Experiment Video
Updated: Jul 10, 2026

Generating Chimeric Zebrafish Embryos by Transplantation
Published on: July 17, 2009
Embryonic stem cell-derived glial precursors: a source of myelinating transplants
O Brüstle1, K N Jones, R D Learish
1Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. brustle@uni-bonn.de
Abstract:
Self-renewing, totipotent embryonic stem (ES) cells may provide a virtually unlimited donor source for transplantation. A protocol that permits the in vitro generation of precursors for oligodendrocytes and astrocytes from ES cells was devised. Transplantation in a rat model of a human myelin disease shows that these ES cell-derived precursors interact with host neurons and efficiently myelinate axons in brain and spinal cord. Thus, ES cells can serve as a valuable source of cell type-specific somatic precursors for neural transplantation.
Related Concept Videos
Embryonic Stem Cells
Fertilization
Cleavage and Blastulation
Zygotic Development And Stem Cell Formation
Embryonic Connective Tissues
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development. Mesenchyme is...

