[Vascular wall modifications after disruption of the circulation leading to cerebral ischemia]

This article describes the modifications occurring in cerebral vessels during the first 24 h after an ischaemic event followed by reperfusion. The phases of occlusion, no-reflow, post-ischaemic hyperaemia and delayed hypoperfusion are dealt with in terms of haemodynamic, morphological, functional and biochemical data, available especially from animal studies. The interactions of platelets and leucocytes with the endothelium and the major role of reactive oxygen species in lesioning the microvasculature, including the blood-brain barrier, are emphasized.