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[Zinc in digestive diseases (author's transl)]
La Nouvelle Presse Medicale
|October 28, 1978
Summary
This review covers zinc metabolism, including its absorption and distribution. It explores zinc deficiency links to gut diseases, diagnostic criteria, and treatment, noting malabsorption in specific conditions.
Area of Science:
- Nutritional Biochemistry
- Gastroenterology
- Human Metabolism
Context:
- Zinc is an essential trace element vital for numerous physiological processes.
- Gut pathology can significantly impact zinc homeostasis and nutritional status.
- Understanding zinc metabolism is crucial for diagnosing and managing various health conditions.
Purpose:
- To review the fundamental aspects of zinc metabolism, including requirements, absorption, distribution, and excretion.
- To examine the intricate relationship between zinc variations and gastrointestinal pathology.
- To discuss diagnostic criteria, pathophysiological mechanisms, clinical outcomes, and therapeutic strategies for zinc deficiency in gut diseases.
Summary:
- The review details zinc's metabolic pathways and its connection to gut health.
- It highlights evidence of zinc malabsorption in Acrodermatitis enteropathica and chronic deficiency in the Middle East.
- Recent findings indicate frequent zinc deficiency in patients receiving total parenteral nutrition, with altered plasma zinc in celiac and inflammatory bowel diseases, though true deficiency requires further confirmation.
Impact:
- Provides a comprehensive overview of zinc's role in gastrointestinal health and disease.
- Clarifies diagnostic approaches and therapeutic implications for zinc-related disorders.
- Identifies areas for future research, particularly concerning zinc status in inflammatory and absorptive enteropathies.