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Intussusception among recipients of rotavirus vaccine--United States, 1998-1999

    MMWR. Morbidity and Mortality Weekly Report
    |July 31, 1999
    PubMed

    Insights

    A rotavirus vaccine (RRV-TV) was linked to 15 infant intussusception cases reported to VAERS. Further studies are ongoing to understand the association between this vaccine and bowel obstruction in infants.

    Area of Science:

    • Pediatrics
    • Vaccinology
    • Gastroenterology

    Background:

    • A tetravalent rhesus-based rotavirus vaccine (RRV-TV) was licensed for infant vaccination in the US in 1998.
    • Routine use of RRV-TV was recommended by major health organizations for healthy infants.

    Purpose of the Study:

    • To summarize clinical and epidemiologic features of intussusception cases in infants who received RRV-TV.
    • To present preliminary data from ongoing studies on intussusception and rotavirus vaccine.

    Main Methods:

    • Analysis of 15 cases of intussusception reported to the Vaccine Adverse Event Reporting System (VAERS) between September 1998 and July 1999.
    • Review of clinical and epidemiological data associated with RRV-TV vaccination.

    Main Results:

    • Fifteen cases of intussusception were reported in infants who had received the RRV-TV vaccine.
    • The Vaccine Adverse Event Reporting System (VAERS) collected these reports during a specific timeframe.

    Conclusions:

    • The study highlights a potential association between RRV-TV and intussusception in infants.
    • Ongoing research is crucial to further investigate this link and inform public health recommendations regarding rotavirus vaccination.

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