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Related Experiment Videos

Collection devices for human papillomavirus.

D M Harper1, A Hildesheim, J L Cobb

  • 1Dartmouth Medical School, Norris Cotton Cancer Center, Hanover, New Hampshire, USA. Diane.M.Harper@Dartmouth.edu

The Journal of Family Practice
|July 31, 1999
PubMed
Summary
This summary is machine-generated.

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Self-collection tampon HPV testing is comparable to physician swabs for detecting human papillomavirus (HPV) in cervicovaginal samples. This indicates its feasibility for large-scale primary care screening studies.

Area of Science:

  • Gynecology
  • Oncology
  • Infectious Diseases

Background:

  • Current human papillomavirus (HPV) testing requires samples collected by healthcare professionals.
  • Self-administered testing devices offer potential for large-scale epidemiologic studies in primary care settings.
  • Development of a self-collection device for cervicovaginal HPV infection is explored.

Purpose of the Study:

  • To determine the feasibility of developing a self-collection device for cervicovaginal HPV infection.

Main Methods:

  • A prospective randomized trial involving 93 women undergoing routine cervical cancer screening.
  • Participants were randomized into two arms: self-administered tampon followed by physician swab, or physician swab followed by self-administered tampon.
  • HPV DNA positivity concordance between sampling methods was assessed using a Hybrid Capture HPV tube test.

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Main Results:

  • The concordance rate for HPV DNA positivity between the self-administered tampon and physician-directed swab was similar in both arms.
  • Concordance rates were 78.3% for arm 1 and 80.9% for arm 2.
  • The tampon demonstrated comparable HPV detection to physician-directed swabs.

Conclusions:

  • The self-collection tampon is equivalent to physician-directed swabs for HPV detection.
  • This self-collection method is feasible for long-term primary care studies involving screening populations.
  • Self-administered HPV testing can expand the reach of cervical cancer screening programs.