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Related Experiment Videos

Chorionic villus sampling in multiple pregnancies.

Z Appelman1, C Vinkler, B Caspi

  • 1Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Israel.

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|July 31, 1999
PubMed
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Chorionic villus sampling (CVS) is safe and accurate for prenatal diagnosis in multiple pregnancies, including twins and triplets. This study confirms its reliability for identifying chromosomal abnormalities.

Area of Science:

  • Perinatology
  • Medical Genetics
  • Obstetrics

Background:

  • Prenatal diagnosis is crucial for managing multiple pregnancies.
  • Chorionic villus sampling (CVS) is a common method for obtaining fetal genetic material.
  • Data on CVS safety and accuracy in higher-order multiples is limited.

Purpose of the Study:

  • To assess the accuracy and safety of chorionic villus sampling (CVS) for prenatal diagnosis in twin and triplet pregnancies.
  • To evaluate the procedural risks associated with CVS in multiple gestations.

Main Methods:

  • Twenty-eight CVS procedures were performed on women with twin pregnancies (24 transabdominal, 4 transcervical).
  • Fifteen CVS procedures were performed on women with triplet pregnancies (14 transabdominal, 1 transcervical).

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Main Results:

  • No sampling failures occurred; one laboratory error was noted in a triplet pregnancy.
  • In twin pregnancies, one abnormal karyotype (47,xy+18) was detected among 28 fetuses.
  • In triplet pregnancies, two cases showed chromosomal abnormalities (mosaic 46,xy/47,xxy) and one fetus had fragile-X syndrome; selective reduction was performed. No spontaneous fetal loss occurred.

Conclusions:

  • Chorionic villus sampling (CVS) is a safe and reliable method for prenatal diagnosis in twin and triplet pregnancies.
  • The procedure demonstrated high accuracy in identifying fetal chromosomal abnormalities in this series.
  • Post-procedure outcomes confirmed the reliability of CVS findings.