Related Experiment Video
Updated: Aug 13, 2026

Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes
Published on: March 2, 2020
In vitro activities of linezolid against important gram-positive bacterial pathogens including vancomycin-resistant
G A Noskin1, F Siddiqui, V Stosor
1Division of Infectious Diseases, Department of Medicine, Northwestern University Medical School, Northwestern Memorial Hospital, Chicago, Illinois 60611, USA. gnoskin@nwu.edu
Abstract:
The emergence of resistance in gram-positive bacteria has necessitated a search for new antimicrobial agents. Linezolid is an oxazolidinone, a new class of antibacterial agents with enhanced activity against pathogens. We compared the activity of linezolid to those of other antimicrobial agents against 3,945 clinical isolates. Linezolid demonstrated potent activity against all isolates tested. For all vancomycin-susceptible enterococci, staphylococci, and streptococci, the activity of linezolid was comparable to that of vancomycin. Against oxacillin-resistant staphylococci and vancomycin-resistant enterococci, linezolid was the most active agent tested. In summary, linezolid appears to be a promising new antimicrobial agent for the treatment of gram-positive infections.
More Related Videos
Related Concept Videos
Antimicrobial Effectiveness
Development of Antibiotic Resistance
Automated Microbial Diagnostics
Inhibitors of Gram-positive Cell Wall Synthesis
Clinical Significance of Antibiotic Resistance

