[Dietary therapy for thrombotic diseases of artery and vein]

Dietary therapy for ameliorating hyperlipidemia consists of several means. First of all, energy restriction is important, especially when the patient is obese. Secondary, restriction of total fat and saturated fatty acid intake is necessary. Energy from fat should be less than 25% of total energy and S:M:P ratio is recommended to be around 1:1-2:1-1.5. Cholesterol intake should be restricted below 300 mg and intake of dietary fiber and vegetable proteins should be increased. Hemostatic factors play an important role in the vessel diseases. A fat-rich diet increases activated factor VII. Many studies have reported inverse association between atherosclerotic disease and n-3 fatty acid consumption. We should maintain the present level of n-3 PUFA intake in Japan by keeping the n-6/n-3 ratio around 4.