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Early T cell receptor beta gene expression is regulated by the pre-T cell receptor-CD3 complex
I Aifantis1, J Feinberg, H J Fehling
1Institut National de la Santé et de la Recherche Médicale (INSERM) U373, Hôpital Necker-Enfants Malades, Paris, France.
The Journal of Experimental Medicine
|August 3, 1999
Abstract:
We have examined the question of whether there is an additional checkpoint in T cell development that regulates T cell receptor (TCR)-beta expression in CD25+44- thymocytes by mechanisms that are independent of the pre-TCR. Our analysis in various mutant mice indicates that all changes in cytoplasmic TCR-beta expression can be accounted for by pre-TCR-dependent signal mediation, putting into question the function of a putative pro-TCR.