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Related Experiment Videos

Patch-test reactions to plastic and glue allergens.

L Kanerva1, R Jolanki, K Alanko

  • 1Section of Dermatology, Finnish Institute of Occupational Health, Helsinki.

Acta Dermato-Venereologica
|August 3, 1999
PubMed
Summary

Occupational skin allergies from plastics and glues are common. Patch testing identified novolac epoxy resin and phenol formaldehyde resin as frequent causes of allergic reactions in patients.

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Area of Science:

  • Dermatology
  • Occupational Health
  • Allergology

Background:

  • Plastics and glues are frequent culprits of occupational dermatoses.
  • Limited research exists on patch-test reactions specifically from plastic and glue allergens.

Purpose of the Study:

  • To investigate the prevalence and types of patch-test reactions to plastic and glue allergens.
  • To identify common allergens causing allergic and irritant contact dermatitis in an occupational dermatology setting.

Main Methods:

  • A 6-year retrospective study of 360 patients referred to an occupational dermatology clinic.
  • Conventional patch testing with 50-53 plastic and glue allergens was performed.
  • Analysis of both allergic and irritant patch-test reaction data.

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Main Results:

  • Novolac epoxy resin (5.1%) and phenol formaldehyde resin (3.1%) were the most common causes of allergic reactions.
  • Benzoyl peroxide (9.5%) and abitol alcohol (3.6%) most frequently elicited irritant reactions.
  • Formaldehyde (5.8%) and diglycidyl ether of bisphenol A (3.2%) were notable allergens in the standard series.

Conclusions:

  • Specific plastic and glue components are significant allergens in occupational contact dermatitis.
  • Even allergens with low positive reaction rates are crucial for diagnosing rare allergies.
  • Negative patch-test results also hold diagnostic value in identifying causative agents.