Related Experiment Videos
Indeterminate findings on imaging-guided biopsy: should additional intervention be pursued?
R D Dameron1, D M deLong, A J Fisher
1Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
AJR. American Journal of Roentgenology
|August 3, 1999
Summary
Indeterminate imaging-guided biopsies have a high malignancy rate (40%). Close follow-up or intervention is crucial for these patients. Sonographic guidance reduces false negatives compared to CT guidance.
Area of Science:
- Radiology
- Pathology
- Oncology
Background:
- Imaging-guided biopsies are essential for diagnosing abdominal lesions.
- Indeterminate biopsy results pose a diagnostic challenge, requiring further evaluation.
Purpose of the Study:
- To determine the malignancy rate in patients with indeterminate imaging-guided biopsy results.
- To identify factors influencing the outcome of indeterminate biopsies.
Main Methods:
- A review of 619 imaging-guided biopsies (CT and sonography) over 25 months.
- Analysis of 129 indeterminate biopsy cases to determine malignancy frequency and influencing factors.
Main Results:
- 40% of indeterminate biopsies were ultimately malignant.
- Sonographic guidance had a significantly lower false-negative rate (28%) than CT guidance (49%).
- Atypical cells in cytologic aspirates were highly predictive of malignancy (71% false-negative rate).
Conclusions:
- A significant proportion of indeterminate biopsies indicate malignancy, necessitating close patient follow-up or intervention.
- Sonographic guidance may improve diagnostic accuracy in indeterminate cases.
- Factors like history of malignancy, needle type, or biopsy site did not significantly impact false-negative rates.