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No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke
M J MacLeod1, M T Dahiyat, A Cumming
1Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, UK.
Neurology
|August 3, 1999
Abstract:
Endothelial nitric oxide synthase (NOS3) gene has been shown to modulate the degree of cerebral ischemia following stroke in animal models and is thus a candidate genetic risk factor for stroke. We compared 265 ischemic stroke cases with 293 controls and found no difference in distribution of the common structural variant Glu/Asp in codon 298 of exon 7 in the NOS3 gene. Our data do not support the hypothesis that NOS3 is a genetic risk factor for stroke.