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Updated: Aug 6, 2026
08:24
Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry
Published on: March 14, 2020
Physiology and pathophysiology of bone remodeling
1Lowell P. Weicker, Jr. General Clinical Research Center, University of Connecticut Health Center, MC-2806, 263 Farmington Ave., Farmington, CT 06030, USA. Raisz@nso.uchc.edu
Clinical Chemistry
|August 3, 1999
Summary
Bone remodeling is a continuous process essential for skeletal integrity and mineral homeostasis. Local and systemic factors regulate this cycle, impacting bone health and disease.
Area of Science:
- Skeletal Biology
- Bone Physiology
- Endocrinology
Background:
- The skeleton is a dynamic, metabolically active organ crucial for structural integrity and mineral storage.
- Bone remodeling, a continuous lifelong process, balances structural and metabolic needs.
- This remodeling cycle involves distinct phases: activation, resorption, reversal, and formation.
Purpose of the Study:
- To elucidate the complex regulation of the bone remodeling cycle.
- To understand the interplay between local and systemic factors in bone metabolism.
- To explore the role of bone remodeling in skeletal diseases.
Main Methods:
- Review of the sequential steps in the bone remodeling cycle.
- Analysis of cellular interactions (osteoblasts, osteoclasts, mesenchymal cells).
- Examination of regulatory factors: hormones, cytokines, prostaglandins, and growth factors.
Main Results:
- Bone remodeling is a highly regulated, multi-phase process involving mesenchymal and hematopoietic cells.
- Systemic factors (hormones) influence overall skeletal growth and mineral balance.
- Local factors (cytokines, growth factors) control mechanical responses, repair, and disease pathogenesis.
Conclusions:
- The bone remodeling cycle is tightly regulated by both systemic and local factors.
- Dysregulation of this cycle contributes to skeletal pathologies like osteoporosis and hyperparathyroidism.
- Understanding these interactions is key to addressing bone diseases.
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