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Apicomplexan plastids as drug targets.

G I McFadden1, D S Roos

  • 1Plant Cell Biology Research Center, School of Botany, University of Melbourne, Parkville, VIC 3052, Australia. g.mcgadden@botany.unimelb.edu.au

Trends in Microbiology
|August 4, 1999
PubMed
Summary

The relict plastid in apicomplexan parasites contains prokaryotic pathways, offering a new drug target. Inhibiting these pathways with herbicides or antibiotics may kill parasites.

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Area of Science:

  • Parasitology
  • Drug Discovery
  • Molecular Biology

Background:

  • Apicomplexan parasites possess a relict plastid with prokaryotic-like metabolic pathways.
  • This plastid is essential for parasite survival and represents a potential drug target.

Purpose of the Study:

  • To explore the potential of targeting apicomplexan plastid metabolic pathways for antiparasitic drug development.
  • To investigate the role of herbicides and antibiotics in inhibiting key plastid functions.

Main Methods:

  • Analysis of prokaryotic metabolic pathways within the apicomplexan plastid.
  • Evaluation of the inhibitory effects of selected herbicides and antibiotics on plastid activities.

Main Results:

  • Identification of key prokaryotic metabolic pathways within the parasite's relict plastid.
  • Evidence suggesting that herbicides and antibiotics can inhibit essential plastid functions, leading to parasiticidal activity.

Conclusions:

  • The apicomplexan relict plastid is a viable and promising target for novel antiparasitic drug development.
  • Inhibition of plastid metabolic pathways by existing drugs like herbicides and antibiotics warrants further investigation for therapeutic applications.

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