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Effects of nimesulide and indometacin on COX-1 and COX-2: a comparative study
X de Leval1, J M Dogné, P Neven
1Department of Medicinal Chemistry, C.H.U., University of Liège.
Journal De Pharmacie De Belgique
|August 4, 1999
Abstract:
Evidence of the existence of two forms of cyclooxygenases and the clinical relevance of COX-2 inhibition led to the development of COX-2 selective NSAIDs. In order to evaluate this selectivity, we have developed and validated an enzymatic method. The precision and reproducibility of the assay were determined and COX-2 selectivity examined using nimesulide and indometacin.