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Phospholipase A2: its usefulness in laboratory diagnostics.

E Kaiser1

  • 1Department of Medical Chemistry, University of Vienna, Austria.

Critical Reviews in Clinical Laboratory Sciences
|August 4, 1999
PubMed
Summary

Phospholipase A2 (PLA2) enzyme assays are valuable for diagnosing and predicting conditions like pancreatitis and septic shock. Elevated PLA2 levels correlate with C-reactive protein, indicating its role as an acute phase protein.

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Area of Science:

  • Biochemistry
  • Enzymology
  • Immunology

Background:

  • Phospholipase A2 (PLA2) is a key enzyme in phospholipid metabolism.
  • PLA2 plays a critical role in inflammatory responses.
  • Understanding PLA2 is crucial for diagnostics and understanding disease pathology.

Purpose of the Study:

  • To review the source, structure, and biological roles of PLA2.
  • To evaluate the utility of PLA2 assays in laboratory diagnostics.
  • To highlight the significance of PLA2 in pathological conditions.

Main Methods:

  • Review of existing literature on PLA2.
  • Discussion of various PLA2 assay methodologies (activity and mass concentration).
  • Presentation of plasma enzyme determinations in patients with diverse pathological conditions.

Main Results:

  • PLA2 is involved in inflammatory mediator production.
  • PLA2 assays are useful for diagnosing pancreatitis, multiple organ failure, septic shock, and rheumatoid arthritis.
  • PLA2 is confirmed as an acute phase protein, correlating with CRP levels.

Conclusions:

  • PLA2 determination offers valuable diagnostic and prognostic information.
  • PLA2 assessment provides deeper insights into certain pathological conditions.
  • While CRP assays are routine, PLA2 analysis offers complementary data for specific disorders.

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