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A cerebral primitive neuroectodermal tumor in a squirrel monkey (Saimiri sciureus).

E H Johnson1, S C Chima, D E Muirhead

  • 1Section of Comparative Medicine, Yale University, School of Medicine, New Haven, CT 06520-8016, USA.

Journal of Medical Primatology
|August 4, 1999
PubMed
Summary
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A squirrel monkey exposed to microwave radiation developed a malignant cerebral primitive neuroectodermal tumor. This aggressive brain tumor showed rapid proliferation and a neuronal cell origin.

Area of Science:

  • Neuro-oncology
  • Toxicology
  • Comparative Pathology

Background:

  • Long-term exposure to environmental factors, such as microwave radiation, may influence the development of central nervous system tumors.
  • Understanding tumor origins and characteristics in non-human primates can provide insights into human neuro-oncology.

Observation:

  • A squirrel monkey with a history of microwave radiation exposure presented with a right cerebral cortex tumor.
  • Gross examination revealed an expanding mass compressing the lateral ventricle.
  • Microscopic analysis showed a tumor with features resembling oligodendroglioma, but with malignant characteristics including nuclear pleomorphism, frequent mitoses, and necrosis.

Findings:

  • Immunohistochemistry confirmed a neuronal cell origin, with positivity for neurofilament proteins and neuron-specific enolase.

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  • Negative staining for vimentin and glial fibrillary acidic protein ruled out glial origin, except for reactive astrocytes.
  • High expression of Ki-67 antigen and p53 oncoprotein indicated aggressive proliferation and malignancy.
  • The tumor was diagnosed as a cerebral primitive neuroectodermal tumor.

    • Implications:

    • This case highlights a potential link between microwave radiation exposure and the development of aggressive brain tumors in primates.
    • The findings contribute to the understanding of rare brain tumor types and their potential environmental triggers.
    • Further research is warranted to investigate the oncogenic effects of microwave radiation on the central nervous system.