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Chorioamnionitis and the prognosis for term infants.

J M Alexander¹, D M McIntire, K J Leveno

¹Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75235-9032, USA. jalexa@mednet.swmed.edu

Obstetrics and Gynecology

|August 4, 1999

Summary

Clinical chorioamnionitis increases neonatal infection risk, but not seizures. Neonatal seizures are linked to labor complications, not maternal infection during labor.

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Area of Science:

Obstetrics and Gynecology
Neonatal Medicine
Perinatal Epidemiology

Background:

Clinical chorioamnionitis is a common complication during pregnancy.
Understanding its impact on neonatal outcomes is crucial for clinical practice.

Purpose of the Study:

To evaluate the association between clinical chorioamnionitis and labor complications with short-term neonatal morbidity.
Specifically to investigate the link between these conditions and neonatal seizures.

Main Methods:

Retrospective cohort study analyzing over 100,000 term infants.
Compared outcomes between infants born to mothers with and without clinical chorioamnionitis.
Chorioamnionitis defined by maternal fever and clinical signs.

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Main Results:

Chorioamnionitis was associated with increased risks of delivery-room intubation, pneumonia, and sepsis.
Neonatal seizures were not significantly linked to chorioamnionitis.
Other labor complications were significantly associated with short-term neurologic morbidity, including seizures.

Conclusions:

The primary short-term neonatal effect of chorioamnionitis is infection.
Short-term neurologic morbidity in newborns is primarily associated with labor complications, not chorioamnionitis itself.