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Stimulation of cytokine and nitric oxide production by acyclic nucleoside phosphonates
1Institute of Pharmacology, Academy of Sciences, Prague, Czech Republic.
Nucleosides & Nucleotides
|August 5, 1999
Abstract:
Several antiviral acyclic nucleotide analogues activate expression of genes for cytokines, such as TNF-alpha, IL-10 in macrophages and IFN-gamma in splenocytes. This is an underlying mechanism for substantially enhanced production of nitric oxide generated by IFN-gamma. More lipophilic prodrugs, bis-POM-PMEA and bis-POC-PMPA, are cytocidal for macrophages and thus inhibit nitric oxide formation.