[The separate and combined use of timoptic depot]

Study of the efficacy of a new long-acting drug timoptic depot (timolol maleate) in 15 patients demonstrated its manifest hypotensive effect. Its administration once a day regulates the level of ophthalmic tone. If additional therapy was needed during treatment with timoptic depot, the best results (more pronounced effect on ophthalmic tone and best tolerance) were observed with combinations of the drug with trusopt or glaucone. Like other nonselective beta-blockers, timoptic depot may cause intraventricular conductivity of the myocardium and sinusoidal bradycardia.