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Mesenteric venous thrombosis associated with protein C deficiency
M Mitani1, Y Kuwabara, H Kawamura
1Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan.
Journal of Gastroenterology
|August 5, 1999
Summary
A patient with abdominal pain and vomiting was diagnosed with superior mesenteric vein thrombosis. Protein C deficiency was identified as a potential cause, highlighting the importance of laboratory evaluation for mesenteric venous thrombosis.
Area of Science:
- Gastroenterology
- Vascular Surgery
- Hematology
Background:
- Mesenteric venous thrombosis (MVT) is a rare but serious condition causing intestinal ischemia.
- Early diagnosis and treatment are crucial for patient survival and outcomes.
Observation:
- An 83-year-old male presented with progressive abdominal pain and vomiting.
- Laparotomy revealed segmental intestinal infarction due to superior mesenteric vein thrombosis.
- Surgical resection of necrotic intestine and successful anastomosis were performed.
Findings:
- The patient received anticoagulation therapy, including heparin, nafamostat mesilate, and aspirin, leading to rapid recovery.
- Laboratory tests identified a deficiency in protein C as the underlying cause.
- Protein S and antithrombin III levels were within normal ranges.
Implications:
- This case underscores the importance of investigating thrombophilic factors in cases of MVT.
- Identifying protein C deficiency can guide long-term anticoagulation strategies and recurrence prevention.
- Laboratory evaluation of coagulation proteins is essential for defining the etiology of MVT.