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Changes of serum and urinary neopterin concentrations in rats after partial hepatectomy
Objective:
To investigate the changes in serum and urinary neopterin concentrations over time after partial hepatectomy in rats, and to find out if neopterin can be used as a marker of immunological response during the regulation of liver regeneration.
Design:
Randomised experiment.
Setting:
University hospital, Taiwan, R.O.C.
Subjects:
84 male Wistar rats weighing about 200g.
Interventions:
Partial hepatectomy (67%) or sham operation (n = 42 in each group).
Main Outcome Measures:
Serum and urinary neopterin concentrations measured by radioimmunoassay preoperatively and on days 1, 2, 3, 5, 7, and 10 postoperatively.
Results:
Serum neopterin concentrations increased and reached their peak on days 5 and 7 after partial hepatectomy. The urinary neopterin concentration showed a similar trend, but with a more pronounced increase on days 5 and 7.
Conclusions:
Serum and urinary neopterin concentrations can be used as markers of activated cell-mediated immunity in rats after partial hepatectomy.