Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcium use increases risk of calciphylaxis: a case-control study.

J M Zacharias1, B Fontaine, A Fine

  • 1Department of Medicine, University of Manitoba, Winnipeg, Canada.

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
|August 5, 1999
PubMed
Summary

Calcium ingestion appears to be a risk factor for calciphylaxis (a condition causing tissue calcification) in patients with renal failure. This study highlights potential links between calcium supplements and the condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simultaneous determination of 8 beta-lactams and linezolid by an ultra-performance liquid chromatography method with UV detection and cross-validation with a commercial immunoassay for the quantification of linezolid.

Talanta·2020
Same author

Observed psychopathology in offspring of parents with major depressive disorder, bipolar disorder and schizophrenia.

Psychological medicine·2019
Same author

Examining predictors of help-seeking behaviours in patients with mood and anxiety symptoms.

Psychiatry research·2018
Same author

Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS.

Journal of neuroinflammation·2015
Same author

Combined theoretical and time-resolved photoluminescence investigations of [Mo₆Brⁱ₈Br(a)₆]²⁻ metal cluster units: evidence of dual emission.

Physical chemistry chemical physics : PCCP·2015
Same author

Genetic testing for BRCA1 and BRCA2 in the Province of Ontario.

Clinical genetics·2015

Area of Science:

  • Nephrology
  • Vascular Biology
  • Mineral Metabolism

Background:

  • Calciphylaxis is a severe condition in renal failure patients, characterized by tissue calcification and high mortality.
  • Risk factors for calciphylaxis remain poorly understood, necessitating further investigation.

Purpose of the Study:

  • To identify risk factors associated with the development of calciphylaxis in patients with renal failure.
  • To explore the role of calcium and vitamin D intake in calciphylaxis pathogenesis.

Main Methods:

  • A retrospective case-control study was conducted at a university hospital peritoneal dialysis center.
  • Eight continuous ambulatory peritoneal dialysis (CAPD) patients with calciphylaxis were matched with controls based on dialysis modality and duration.
  • Multivariate conditional logistic regression analyzed laboratory data, demographics, and cumulative calcium and vitamin D intake.

Related Experiment Videos

Main Results:

  • Female patients were significantly more likely to develop calciphylaxis (p < 0.0001).
  • While not statistically significant, a majority of calciphylaxis patients were diabetic.
  • Calcium carbonate intake showed a trend towards increased risk of calciphylaxis (p = 0.0556).
  • Iron intake appeared to be protective, contrary to previous findings.

Conclusions:

  • Calcium ingestion, particularly from calcium salts used as phosphate binders, may be a risk factor for calciphylaxis.
  • The study confirms a higher prevalence of female diabetics among calciphylaxis cases.
  • Further research is needed to elucidate the complex etiology of calciphylaxis.