Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Idiopathic pinealitis. Case report.

D C Nikas1, U De Girolami, A A Zamani

  • 1Neurosurgical Laboratories, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. dnikas@rics.bwh.harvard.edu

Journal of Neurosurgery
|August 5, 1999
PubMed
Summary

A rare case of chronic inflammation mimicking a pineal tumor caused a 63-year-old man to feel like falling. Surgical resection revealed inflammatory cells, not neoplasia, resolving his symptoms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of WALANT in hallux valgus correction: Anesthetic protocol and technical considerations.

Revista espanola de cirugia ortopedica y traumatologia·2026
Same author

Use of WALANT in hallux valgus correction: Anesthetic protocol and technical considerations.

Revista espanola de cirugia ortopedica y traumatologia·2026
Same author

Neurofilament light chain and profilin-1 dynamics in 30 spinal muscular atrophy type 3 patients treated with nusinersen.

European journal of neurology·2024
Same author

Long-term effect of anticancer therapy on dentition of Italian children in remission from malignant disease: A cross-sectional study.

European journal of paediatric dentistry·2022
Same author

Lacosamide in monotherapy in BTRE (brain tumor-related epilepsy): results from an Italian multicenter retrospective study.

Journal of neuro-oncology·2022
Same author

The effect of an oral spray containing an aqueous extract of Triticum vulgare on dental plaque and gingival inflammation in schoolchildren: A randomized controlled trial.

European journal of paediatric dentistry·2020

Area of Science:

  • Neuroscience
  • Pathology
  • Oncology

Background:

  • Pineal region masses can present with varied neurological symptoms.
  • Differentiating inflammatory lesions from neoplastic processes in the pineal gland is critical for accurate diagnosis and treatment.

Observation:

  • A 63-year-old male presented with a 3-month history of a "feeling of falling backward."
  • Magnetic resonance imaging (MRI) revealed an enhancing mass in the posterior third ventricle.
  • Surgical exploration identified a diffusely enlarged pineal gland.

Findings:

  • Histopathological examination of the resected pineal lesion showed a dense chronic inflammatory cell infiltrate, including T and B lymphocytes, macrophages, eosinophils, and mast cells.
  • Immunoperoxidase studies and microbial searches were negative for neoplastic cells, Langerhans cells, or microorganisms.

Related Experiment Videos

  • The lesion was definitively characterized as a non-neoplastic inflammatory process.

    • Implications:

    • This case highlights the importance of considering inflammatory conditions in the differential diagnosis of pineal region masses.
    • Accurate histopathological analysis is crucial to avoid misdiagnosis of neoplastic disease.
    • Successful resection of the inflammatory mass led to an uneventful postoperative course, suggesting inflammatory lesions are treatable.