Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelial dysfunction and hypertensive vasoconstriction.

A A De Artinano1, V L Gonzalez

  • 1Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense de Madrid, Ciudad Universitaria s/n., Madrid, 28040, Spain.

Pharmacological Research
|August 6, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Highlights on endothelins: a review.

Pharmacological research·1998
Same journal

Ketohexokinase: A central mediator of fructose-associated pathogenesis and promising therapeutic target.

Pharmacological research·2026
Same journal

GLP-1-based combination strategies for weight loss: Multi-target agents and combination therapies.

Pharmacological research·2026
Same journal

Cajaninstilbene acid in macrophage immunometabolism and angiogenesis: Mechanisms and therapeutic potential.

Pharmacological research·2026
Same journal

From Mechanisms to Therapy: Targeting the Gut-Brain Axis in Chronic Gastrointestinal Pain.

Pharmacological research·2026
Same journal

Natural product emodin-based nanodrug delivery systems: Advancements and applications.

Pharmacological research·2026
Same journal

Targeting androgen receptor transcriptionally represses VCP and enhances the efficacy of oncolytic-immunotherapy in hepatocellular carcinoma.

Pharmacological research·2026
See all related articles

Essential hypertension involves endothelial dysfunction and increased free radicals, impacting nitric oxide and leading to vasoconstriction. Antioxidants and specific antihypertensives may help by reducing free radical production.

Area of Science:

  • Cardiovascular Physiology
  • Endothelial Function
  • Hypertension Pathophysiology

Background:

  • Endothelial dysfunction is common in essential hypertension, affecting nitric oxide synthesis and function.
  • Hypertensive vasoconstriction is linked to free radical degradation of nitric oxide, particularly superoxide anions.
  • Xanthine oxidase activity contributes to free radical formation, while superoxide dismutase normally neutralizes them.

Purpose of the Study:

  • To explore the role of endothelial dysfunction and free radicals in arterial hypertension.
  • To investigate the contribution of xanthine oxidase, superoxide dismutase, and cyclo-oxygenase pathways.
  • To examine the involvement of endothelin-1 in hypertensive vasoconstriction.

Main Methods:

  • Review of existing literature on endothelial function in hypertension.

Related Experiment Videos

  • Analysis of the biochemical pathways involving free radicals (superoxide anion) and enzymes (xanthine oxidase, superoxide dismutase).
  • Examination of vasoconstrictor mechanisms including cyclo-oxygenase products and endothelin-1.

    • Main Results:

    • Increased free radical production or decreased superoxide dismutase activity is observed in hypertension.
    • Dysfunctional endothelium releases vasoconstrictor peroxides via cyclo-oxygenase activity, amplified by free radicals.
    • Endothelin-1, a potent vasoconstrictor, may increase locally and potentiate other vasoconstrictors, potentially releasing free radicals.

    Conclusions:

    • Increased vasoconstriction in arterial hypertension is associated with heightened free radical production.
    • Antioxidant agents and xanthine oxidase inhibitors are potential treatments for hypertension and endothelial dysfunction.
    • Some antihypertensive drugs may exert benefits by inhibiting free radical production.